NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication
نویسندگان
چکیده
منابع مشابه
CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination.
The conserved MRE11–RAD50–NBS1 (MRN) complex is an important sensor of DNA double-strand breaks (DSBs) and facilitates DNA repair by homologous recombination (HR) and end joining. Here, we identify NBS1 as a target of cyclin-dependent kinase (CDK) phosphorylation. We show that NBS1 serine 432 phosphorylation occurs in the S, G2 and M phases of the cell cycle and requires CDK activity. This modi...
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Homologous pairing during meiotic prophase is essential for homologous recombination and for chromosome segregation during meiosis I; yet, it is largely unknown how homologues approach each other. A chromosomal rearrangement called the telomere bouquet in early meiotic prophase is thought to play a key role in homologous pairing (Scherthan, 2001; Harper et al., 2004). It forms as telomeres clus...
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Telomeres, the ends of linear eukaryotic chromosomes, have a specialized chromatin structure that provides a stable chromosomal terminus. In budding yeast Rap1 protein binds to telomeric TG repeat and negatively regulates telomere length. Here we show that binding of multiple Rap1 proteins stimulates DNA double-stranded break (DSB) induction at both telomeric and non-telomeric regions. Consiste...
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متن کاملMismatch repair during homologous and homeologous recombination.
Homologous recombination (HR) and mismatch repair (MMR) are inextricably linked. HR pairs homologous chromosomes before meiosis I and is ultimately responsible for generating genetic diversity during sexual reproduction. HR is initiated in meiosis by numerous programmed DNA double-strand breaks (DSBs; several hundred in mammals). A characteristic feature of HR is the exchange of DNA strands, wh...
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ژورنال
عنوان ژورنال: DNA Repair
سال: 2009
ISSN: 1568-7864
DOI: 10.1016/j.dnarep.2009.09.002